- Strool
- Summerville
- Schmidt Landing
- Shady Beach
- Skeleton Island
- Skunk Island
- South Dakota Park
- Spring Grove
- Spink Colony
- Spottswood
- Sharps Corner
- Slim Butte
- Sand Island (historical)
- Sego Island (historical)
- Sansarc
- Sinai
- Sioux Falls
- Sisseton
- Saint Onge
- Scenic
- Shadehill
- Silver City
- Smithwick
- Sorum
- Spink
- Stamford
- Stephan
- Stoneville
- Spearfish
- Storla